Paediatric Acute care Guidelines PMH Emergency Department


Calcium gluconate 10% solution = 0.22mmol/ml Ca


  • Treatment of calcium deficiency
  • As an adjunct in hyperkalaemia
  • As an inotrope (in PICU)


  • Vasodilation leading to hypotension
  • Nausea, vomiting, hot flushes and sweating
  • IV and IM can cause local tissue reactions including irritation and necrosis
  • Excreted mainly in urine but also found in faeces and saliva, sweat, breast milk, bile and pancreatic juice



  • IM & S/C not recommended
  • Not to be given via ETT
  • Intravenous              
    • Dose:  0.5ml/kg of 10% solution (maximum 20 mls)
    • Given via large peripheral vein or CVC only
    • Can be given neat as a SLOW IV push over 3-5 minutes
    • For IV infusion – Calcium Gluconate can be neat or diluted to half strength and given over 1 hour. If continuous infusion, syringe should be used in 24 hours.
    • Can be added to TPN            
    • In cardiac arrest can be given over 10-20 secs



  • Serum calcium levels should be carefully monitored
  • ECG should be monitored
  • Extravasation should be avoided – give through a CVC when possible
  • Care in patients with renal failure


  • Glucose 5%, Normal Saline, Hartmann’s
  • Amikacin, aminophylline, amioderone, aztreonam, benzylpenicillin, cefepime, dexmedetomidine, frusemide, heparin, hydrocortisone, labetalol, lignocaine, linezolid, magnesium sulphate, metaraminol, midazolam, milrinone, noradrenaline, phenobarbitone, piperacillin-tazobactam, potassium chloride, propofol, remifentanil, tobramycin, vancomycin, verapamil.


Incompatible with:

  • Adrenaline, amphotericin B2, ampicillin, cefalotin, ceftriaxone, cephalothin, cephamandole, clindamycin, dexamethasone,sodium phosphate, diazepam, digoxin, dobutamine, flucloxacillin, fluconazole, meropenem, methylprednisolone, metoclopramide, pantoprazole, phenytoin, phosphate salts, prochlorperazine, sodium bicarbonate


PMH ED Guidelines – Calcium Gluconate 10% – last updated September 2014
PICU Drug File Reviewed October 2012  
The Extra Pharmacopoeia 35th Edition (2007) Martindale,
EMIMS 2012
Australian Injectable Drugs Handbook 5rthEdition (2011)
The Society of Hospital Pharmacists of Australia
Shann, F. Drug Doses (2010) 15th Edition
Paediatric Dosage Handbook International 17th Edition (2011)
Taketomo, CK, Hodding, JH & Kraus, DM.
Drug Manufacturer Product Information
E/Clinical Pharmacology 2012


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